CONOLIDINE ALKALOID FOR CHRONIC PAIN NO FURTHER A MYSTERY

Most a short while ago, it has been discovered that conolidine and the above derivatives act around the atypical chemokine receptor three (ACKR3. Expressed in similar locations as classical opioid receptors, it binds into a wide array of endogenous opioids. Contrary to most opioid receptors, this receptor functions as a scavenger and won't activate